Monday, January 6, 2020
The Hypothesis That Increased Glucagon Like Peptide
VII. Current Research A. Study by Mayo Clinic, Rochester, Minnesota (Adrian Vella, M.D. Principal Investigator) 1. Studied the hypothesis that increased glucagon-like peptide 1 (GLP-1) secretion explains the improvement in insulin secretion after Roux-en-Y Gastric Bypass (RYGB) Surgery (therapeutic long-term treatment for patients with morbid obesity and type 2 diabetes mellitus) a) Ã¢â¬Å"The overall metagenomic RYGB-induced shift was characterized by a reduction of Firmicutes and Bacteroidetes and an increase of Proteobacteria . . . Highly correlated species [of bacterium] were assembled into two common components. Component 1 consisted of species that were mainly associated with BMI and C-reactive protein. This component was characterized byÃ¢â¬ ¦show more contentÃ¢â¬ ¦C. Newcastle University Study 1. Researchers conducted a study where patients did 90 second intervals of intense exercise (cycling) and observed the effects it had on the heart. It Ã¢â¬Å"improved cardiac structure and heart function, particularly the left ventricle, which is altered by the development of type 2 diabetesÃ¢â¬ as well as helped with maintaining a normal blood sugar level (Wood 2). D. Various studies with Vitamin D Experimentation 1. Study D2d, principal investigator Anastassios G. Pittas, M.S., M.D., large scale clinical trial funded by NIH a) Investigation of whether vitamin D supplementation helps prevent or delay type 2 diabetes in pre-diabetic adults (The D2d Study is Underway 1). 2. Another study researched whether vitamin D was a predictor of all-cause and cardiovascular mortality and risk of progression to micro- or macroalbuminuria in type 2 diabetic patients. a) The study concluded that Ã¢â¬Å"severe vitamin D deficiency predicts increased risk of all-cause and cardiovascular mortality, independent of UAER and conventional cardiovascular risk factors. Whether vitamin D substitution improves prognosis remains to be investigatedÃ¢â¬ (Vitamin D levels and mortality in type 2 diabetes 1). b) Study was conducted in 2010 but Vitamin D is still being investigated as a possible factor in prevention/controlling of diabetes today. E.