The Hypothesis That Increased Glucagon Like Peptide

VII. Current Research A. Study by Mayo Clinic, Rochester, Minnesota (Adrian Vella, M.D. Principal Investigator) 1. Studied the hypothesis that increased glucagon-like peptide 1 (GLP-1) secretion explains the improvement in insulin secretion after Roux-en-Y Gastric Bypass (RYGB) Surgery (therapeutic long-term treatment for patients with morbid obesity and type 2 diabetes mellitus) a) â€Å"The overall metagenomic RYGB-induced shift was characterized by a reduction of Firmicutes and Bacteroidetes and an increase of Proteobacteria . . . Highly correlated species [of bacterium] were assembled into two common components. Component 1 consisted of species that were mainly associated with BMI and C-reactive protein. This component was characterized by†¦show more content†¦C. Newcastle University Study 1. Researchers conducted a study where patients did 90 second intervals of intense exercise (cycling) and observed the effects it had on the heart. It â€Å"improved cardiac structure and heart function, particularly the left ventricle, which is altered by the development of type 2 diabetes† as well as helped with maintaining a normal blood sugar level (Wood 2). D. Various studies with Vitamin D Experimentation 1. Study D2d, principal investigator Anastassios G. Pittas, M.S., M.D., large scale clinical trial funded by NIH a) Investigation of whether vitamin D supplementation helps prevent or delay type 2 diabetes in pre-diabetic adults (The D2d Study is Underway 1). 2. Another study researched whether vitamin D was a predictor of all-cause and cardiovascular mortality and risk of progression to micro- or macroalbuminuria in type 2 diabetic patients. a) The study concluded that â€Å"severe vitamin D deficiency predicts increased risk of all-cause and cardiovascular mortality, independent of UAER and conventional cardiovascular risk factors. Whether vitamin D substitution improves prognosis remains to be investigated† (Vitamin D levels and mortality in type 2 diabetes 1). b) Study was conducted in 2010 but Vitamin D is still being investigated as a possible factor in prevention/controlling of diabetes today. E.